Sıçanlarda Asetaminofen Kaynaklı Uterin ve Fallop Tüpleri Hasarına Karşı Eksozomların Kullanımı Üzerine Deneysel Bir Çalışma

Acetaminophen (APAP) is an antipyretic and analgesic drug that can be bought used without a prescrip- tion worldwide. A dosage of APAP greater than the maximum recommended increase risk organ damage. Mesenchymal stem cells (MSCs) are isolated from various human tissues for therapy, in which beneficial effects attributed mainly to mesenchymal cell-derived extracellular vesicles (MSC-EVs). However, no study has focused on protective effect exosomes combination with APAP. Therefore, present was carried out investigate taking against toxicity fallopian tubes uterus. Forty female Wistar albino rats (12–14 weeks old) were randomly divided into four equal groups: control, (received 1 g/kg APAP), exosome 30 μg exosomes), APAP+exosome groups received simultane- ously followed three days later by tail vein injection exosomes. The uterus fallo- pian removed histological immunohistochemical analyses after animals sacrificed. results showed exosomes' administration decreased APAP's autophagic effects. Moreover, treatment exhibited immunoreactivity intensities autuphagy markers (Beclin-1, p62, LC3). treatments had adverse or tubes. exo- somes decrease cell death through autophagy It suggested this com- pound toxic Further studies needed evaluate molecular mechanism hyperanalgesic effect.